{
  "baselines": {
    "direct_overlap": {
      "denominator": 1874,
      "hitsAt1": 143,
      "hitsAt10": 182,
      "hitsAt5": 163,
      "mrrAt10": 0.08161114,
      "paperMacroTop5": 0.05736375,
      "papers": 204,
      "top5Rate": 0.08697972
    },
    "gene_breadth": {
      "denominator": 1874,
      "hitsAt1": 115,
      "hitsAt10": 116,
      "hitsAt5": 116,
      "mrrAt10": 0.06147279,
      "paperMacroTop5": 0.00980392,
      "papers": 204,
      "top5Rate": 0.06189968
    }
  },
  "byYear": {
    "2024": {
      "denominator": 1312,
      "hitsAt1": 124,
      "hitsAt10": 186,
      "hitsAt5": 167,
      "mrrAt10": 0.11105788,
      "paperMacroTop5": 0.08858614,
      "papers": 136,
      "top5Rate": 0.12728659
    },
    "2025": {
      "denominator": 562,
      "hitsAt1": 4,
      "hitsAt10": 5,
      "hitsAt5": 5,
      "mrrAt10": 0.00800712,
      "paperMacroTop5": 0.07352941,
      "papers": 68,
      "top5Rate": 0.0088968
    }
  },
  "clinvarAnnotation": {
    "casesWithExactHistoricalSnv": 356,
    "casesWithHistoricalGeneAgreement": 356,
    "casesWithReportedSnv": 1358,
    "exactHistoricalSnvCaseRows": 361,
    "geneAgreementCaseRows": 361,
    "mappedGeneCaseRows": 361,
    "reportedSnvCaseRows": 1444,
    "uniqueHistoricalSnvsMatched": 125,
    "uniqueReportedSnvs": 691
  },
  "denominator": 1874,
  "development": {
    "direct_overlap": {
      "denominator": 1054,
      "hitsAt1": 12,
      "hitsAt10": 42,
      "hitsAt5": 27,
      "mrrAt10": 0.01804388,
      "paperMacroTop5": 0.04925198,
      "papers": 164,
      "top5Rate": 0.0256167
    },
    "gene_breadth": {
      "denominator": 1054,
      "hitsAt1": 6,
      "hitsAt10": 6,
      "hitsAt5": 6,
      "mrrAt10": 0.0056926,
      "paperMacroTop5": 0.00609756,
      "papers": 164,
      "top5Rate": 0.0056926
    },
    "semantic_ic": {
      "denominator": 1054,
      "hitsAt1": 27,
      "hitsAt10": 89,
      "hitsAt5": 62,
      "mrrAt10": 0.04128867,
      "paperMacroTop5": 0.075271,
      "papers": 164,
      "top5Rate": 0.05882353
    }
  },
  "evaluated": 1873,
  "evidenceSha256": "642d4d33324fcb60a7a5dc42a7d2eb168be0ca5f81e108e03a337c0af26ebf70",
  "historicalGeneProfiles": {
    "filteredHistoricalRows": {
      "non_phenotypic_or_obsolete_rows": 13385,
      "unmapped_ncbigene_rows": 168
    },
    "genes": 4892,
    "profiles": 11820
  },
  "historicalHpoCitationOverlapPapers": 0,
  "hitsAt1": 128,
  "hitsAt10": 191,
  "hitsAt5": 172,
  "knownAssociation": {
    "denominator": 377,
    "hitsAt1": 125,
    "hitsAt10": 184,
    "hitsAt5": 166,
    "mrrAt10": 0.38616164,
    "paperMacroTop5": 0.35034241,
    "papers": 42,
    "top5Rate": 0.4403183
  },
  "knownGene": {
    "denominator": 702,
    "hitsAt1": 128,
    "hitsAt10": 191,
    "hitsAt5": 172,
    "mrrAt10": 0.21397142,
    "paperMacroTop5": 0.21046561,
    "papers": 81,
    "top5Rate": 0.24501425
  },
  "misses": {
    "belowTop5OrTied": 529,
    "geneMissingFromHistoricalKnowledge": 1172,
    "noUsableHpo": 1
  },
  "modelFit": "no_case_training_or_tuning",
  "mrrAt10": 0.08015365,
  "paperMacroTop5": 0.08356723,
  "papers": 204,
  "predictionSha256": "ac5654bab164e40bb9c4c2ea15c7f6b8db5d57dac76f3f0ba8e99ccd83cd401c",
  "runCodeSha256": {
    "prepare.py": "c84645a01609a10a6a587b628cee58a0db67a0170f5876c42b741606dddd8a2d",
    "rank.py": "bfc2d1fd9582cf3cae81285c24746b47538a6a53840386723106f05672feb0b3",
    "score.py": "47837e6a18f7d0056e9a8621bf635b3a40ecca92c2e1b1618a035d7ee409c79b"
  },
  "scope": "published_case_phenotype_rank",
  "sourceHashes": {
    "associations": "a66d2b20b916e19cf568bc450407e3c41d235b1efbc068046d36483591f8cc49",
    "citations": "12f11d613f87f04b16e57b9b118c107132f2a5ed445f11a5eed89ee02001a330",
    "clinvar": "00b397cde4a46755371897ff6054a84044950c19e0c196a4f8abababb768aaf4",
    "hgnc": "3cb0f6f85262ce5d1d7ad52d8ef81e0b5a9cd4536ada39f2911bdfc3b6a1176c",
    "ontology": "978a9afc2e6fb82db5f2544f98ff25fbd6d9f052c459a35454a1303f1255e092",
    "phenopackets": "d0c70005bb09b87035087516252b6b539fbc0415be7c664b73c9cde7eedf205a"
  },
  "split": {
    "counts": {
      "after_window": 68,
      "corpus": 10377,
      "development": 1054,
      "excluded_exact_signature": 5,
      "no_positive_hpo": 3,
      "non_unique_causative_hgnc": 69,
      "reference": 7304,
      "test": 1874
    },
    "papersByPartition": {
      "after_window": 11,
      "development": 164,
      "reference": 1352,
      "test": 204
    },
    "protocolSha256": "02576c5b3d9e2f9a5fe79da40855886f381eee0ba2dea83569c5375074660b1d",
    "uniquePapersInCorpus": 1733
  },
  "splitLockSha256": "51ffff7e933738a81750d90d43357f402054f61fd3869d89cbd0238a66944d42",
  "targetMet": false,
  "top5PaperClusterBootstrap95": [
    0.01207729,
    0.20960521
  ],
  "top5Rate": 0.09178228,
  "top5Target": 0.9,
  "usableHpoCaseCount": 1873,
  "withoutExactHistoricalAssociation": {
    "denominator": 1497,
    "hitsAt1": 3,
    "hitsAt10": 7,
    "hitsAt5": 6,
    "mrrAt10": 0.00308951,
    "paperMacroTop5": 0.01440329,
    "papers": 162,
    "top5Rate": 0.00400802
  }
}